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Bioavailability
Reboot

Maxicuma® is Clinically studied to deliver
172 folds more free Curcumin compared to standardized curcumin 95%

Published in the Journal of Current Research of Complementary and Alternative Medicine 7: 191.
Get access of the full published version here –

In an open-label, non-randomized, two-period, single dose, two-group crossover study with the total duration of 21 days (including 14 days washout period), on healthy adults, under fasting conditions, Maxicuma® exhibited (in comparison with standardized curcumin 95%):

Maxicuma v/s Micronized
Curcumin 95%

AUCt (ng.h/ml)

Free Curcumin
  • 2700
  • 900
Free DMC
  • 800
  • 250
Free BDMC
  • 150
  • 50
  • Maxicuma
  • Micronized Curcumin 95%
Read More
  • 172 Folds

    more free
    curcumin

  • 2.4 Times

    higher Cmax

    (time to peak plasma concentration)

  • 1.6 Times

    faster Tmax

    (maximum peak plasma concentration)

  • 3 Times

    Higher Total AUCt

    (total area under t-curve)

Do bioavailability numbers always ensure efficacy?

Active constituent

The Free Curcumin component in blood plasma is responsible for biological action.

Research suggests that the level of efficacy is best determined by the levels of unmetabolized free curcumin in the ingredient

Inactive Constituents

Excreted rapidly, producing little or no biological activity.

Curcumin
Bioavailability - The
GOLD Standards:

Most of the new generation curcumin ingredients claim higher bioavailability, as they reflect the total curcuminoid levels without specifying the metabolites and free curcumin (unmetabolized major bioactive) in their product, misleading the formulators with tall claims.

The right way of measuring and reporting every curcuminoid compounds in its free form, as well as it’s respective metabolite, is the gold standard of measuring the bioavailability of turmeric ingredients, as performed in studies investigating Maxicuma®.

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or technology platforms

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